I don't drink and hence don't go to places like nightclub. On weekends I regularly go to climbing gym but we (I?) generally just keep to ourselves and focus on the activity so there is little interaction. EDIT: specifically asking about Bay Area
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Meet ups or other interest based groups. Increases chance of finding a romantic partner with some common interest—or at least to meet new friends.
Meetup.com is a great way to meet like minded people
Supposedly parties are good to meet friends of friends but the internet works really well for me.
Skiing and biking. I don't drink either but went clubbing anyhow and had a lot of fun that way. Met lots of good people, we're still friends years later even though we hardly ever go to clubs anymore.
Burning Man communities can be really fun with interesting people if you have an open mind.
Explore your hobbies. Going out all the time isn't really going to be as easy to find lots of new people
don’t go nightclubs, wasting health and money. go church, gym, join interest meetups (meetup.com) etc. try to find some friends or coworkers to hang out with over weekends. you will get to know more people thru them.