Dapi News

Dapi Dove Medical Press / May 5, 2021

Central nervous system (CNS) inflammation alters neurotransmission, affects neuronal death, regeneration, and neuroplasticity, and is involved in the pathophysiology of neurological diseases. When activated by harmful stimuli, such as trauma, infection, and oxidative factors, inflammatory cells secrete abnormal levels of proinflammatory cytokines and amplify the response of other immune cells, leading to clinical symptoms of inflammation.

https://www.dovepress.com/lycopus-lucidus-turcz-exerts-neuroprotective-effects-against-h2o2-indu-peer-reviewed-fulltext-article-JIR
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Lycopus lucidus Turcz, regulating inflammatory disorders | JIR

Dove Medical Press

Dapi Science Advances / Apr 30, 2021

RNA-based therapies offer unique advantages for treating brain tumors. However, tumor penetrance and uptake are hampered by RNA therapeutic size, charge, and need to be "packaged" in large carriers to improve bioavailability. Here, we have examined delivery of siRNA, packaged in 50-nm cationic lipid-polymer hybrid nanoparticles (LPHs:siRNA), combined with microbubble-enhanced focused ultrasound (MB-FUS) in pediatric and adult preclinical brain tumor models.

https://advances.sciencemag.org/content/7/18/eabf7390.full
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Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

Science Advances

Dapi Lab + Life Scientist / Apr 30, 2021

Cell-based assays have a variety of practical uses within scientific research and are an integral component of many scientists' workflows, from testing tumour resistance for cancer research to helping identify novel therapeutic compounds in drug discovery. They are often used as an in vitro tool to measure the number of cells at different time points throughout an experiment.

https://www.labonline.com.au/content/life-science-clinical-diagnostics-instruments/sponsored/real-time-image-cytometry-in-a-plate-reader-capturing-the-whole-story-605743046
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Real-time image cytometry in a plate reader: capturing the whole story

Lab + Life Scientist

Dapi Dove Medical Press / Apr 28, 2021

In 2018, there were 100,000 new cases of gastric cancer (GC) and 783,000 deaths worldwide. Genetics and diet are acknowledged risk factors for GC. Recurrence and metastasis occur in more than half of patients who undergo radical gastrectomy. A low BECN1 level is related to a poor prognosis for GC, which suggests autophagy as a potential antitumor target.

https://www.dovepress.com/mir-140-3p-impedes-gastric-cancer-progression-and-metastasis-by-regula-peer-reviewed-fulltext-article-OTT
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miR-140-3p targeting BCL2/BECN1-induced autophagy | OTT

Dove Medical Press

Dapi Dove Medical Press / Apr 28, 2021

Rectal cancer is one of the most common malignant tumors. It currently ranks third in the world's most common cancer and the fourth most common cause of cancer-related death in the world. Due to the improvement of living standards and changes in environment and lifestyle, the incidence rate and risk factors also increased, and the age of onset is becoming younger.

https://www.dovepress.com/lncrna-egotmir-211-5p-affected-radiosensitivity-of-rectal-cancer-by-co-peer-reviewed-fulltext-article-OTT
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LncRNA EGOT/miR-211-5p Affected Radiosensitivity of Rectal Cancer by C | OTT

Dove Medical Press

Dapi Dove Medical Press / Apr 28, 2021

Glioma, a common primary tumor in the central nervous system, mostly occurs at the neuroectoderm. The incidence of glioma accounts for about 45-50% of intracranial tumors. Currently, glioma is mainly treated by surgery combined with multiple treatments, such as radiotherapy, chemotherapy, and tumor biological activation immune method, but the treatment outcome of glioma is far from satisfactory.

https://www.dovepress.com/mycnbs1-mediated-dna-damage-response-is-involved-in-the-inhibitory-eff-peer-reviewed-fulltext-article-DDDT
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MYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Ef | DDDT

Dove Medical Press

Dapi Dove Medical Press / Apr 28, 2021

Diabetic nephropathy (DN), one of the most common diabetic complications, is the principal cause of chronic kidney disease and end-stage renal disease which leads to global health and socioeconomic burdens on human beings. It is estimated that approximately 30-50% of the patients with type 1 or type 2 diabetes develop symptoms of DN during their lifetime, which results in a high mortality rate.

https://www.dovepress.com/forsythoside-a-alleviates-high-glucose-induced-oxidative-stress-and-in-peer-reviewed-fulltext-article-DMSO
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Forsythoside A- potential treatment for diabetic nephropathy | DMSO

Dove Medical Press

Dapi Dove Medical Press / Apr 23, 2021

Liver cancer has become the third leading cause of cancer-associated mortality worldwide. The main therapeutic methods for liver cancer include radical resection and chemotherapy. The treatment of liver cancer has made significant progress in the past few years. However, the prognosis of liver cancer remains poor.

https://www.dovepress.com/a-novel-circular-rna-circcspp1-promotes-liver-cancer-progression-by-sp-peer-reviewed-fulltext-article-OTT
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RNA circCSPP1 promotes liver cancer progression | OTT

Dove Medical Press

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