Is taking a day off outside your PTO looked down upon at your company?

It seems like people mostly use their PTO but hardly ever take other days off. I don't mind losing 2 weeks worth of salary in a year if it means I get to spend 2 extra weeks with family. In addition to the monetary loss, does a company look down upon this even in I inform them well in advance?

(In addition to voting please post your thoughts if any)

EDIT:

From the 60-odd votes till now, over 40% of you have never even tried or considered taking time off after PTO!! For those of you 40% who want to take time off, but are not doing so because you're too lazy or afraid to ask - go on that holiday or spend time with your loved ones! From the list of top 10 things people regret in their old age, they wish they:

(9) Hadn't worked so hard
(7) Had taken better care of their body
(3) Had given back more to charity
(2) Had pursued their dreams and aspirations and not what others expected of them
And
(1) Had spent more time with people they care about

(According to some YouTube video)