Fugro has completed fieldwork on a geophysical, geotechnical and environmental site investigation contract for RWE Renewables’ Dogger Bank South offshore wind farm and export cable routes.
We explored biomarkers associated with the development of primary immune thrombocytopenia from an immune perspective to inform the clinical diagnosis.
The goal of this study was to investigate the toxicity of zinc oxide nanoparticles (ZnO NPs) in female mice ovaries and explore its potential mechanism.
VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informing the design of VRC01-class targeting immunogens.
CRISPR-CATCH is used to isolate extrachromosomal DNA (ecDNA) molecules containing oncogenes from human cancer cells. CRISPR-CATCH followed by nanopore sequencing allows for methylation profiling, highlighting differences from the native chromosomal loci.
Created for fashion executives and students around the world, the complimentary new series will debut online on October 17, 2022 NEW YORK - October 15, 2022 -
Background Dengue is the fastest spreading arboviral disease, posing great challenges on global public health. A reproduceable and comparable global genotyping framework for contextualizing spatiotemporal epidemiological data of dengue virus (DENV) is essential for research studies and collaborative…
Our study might provide new strategies for improving the clinical efficacy of temozolomide on glioma.
Plant genotype alone appears to be insufficient to explain trait variations. This study integrates GWAS, MWAS and mGWAS in 827 foxtail millet cultivars, revealing that root-associated microbiota affect plant phenotypes in a host genotype-dependent manner.
The ISME Journal - Cryptic and ubiquitous aplastidic cryptophytes are key freshwater flagellated bacterivores
Comprehensive profiling of ligand-induced perturbation responses of the MCF10A mammary epithelial cell line provides an exhaustive resource for identification of the molecular basis of cellular phenotypes.
Molecular Psychiatry - Insulin modulates emotional behavior through a serotonin-dependent mechanism
Fluorescence proximity sensing enables high throughput determination of binding affinities and kinetics of peptide inhibitors with varying valency and multivalent architecture.
Using individual transcriptomes of two ant species, the authors show that caste differentiation is canalized from early development and identify key regulatory genes for the development of ant caste phenotypes.
Analysis of mouse oocyte epigenomics and cytoplasmic rearrangements provides insights into a developmentally important transitional phase in late oogenesis and dynamic changes of TET-enzyme mediated DNA modifications.
Scientific Reports - Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani
The disaccharide trehalose is a synergistic cosolute and key biomarker of desiccation tolerance in tardigrades.
In silico and in vitro investigations reveal angular differences in the blood vessel branching points differentially alter the hemodynamics to impact endothelial structure and function.
Sustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice
A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry in…